An Overview of Major Genes Affecting Prolificacy in Sheep and Related Mechanisms

Authors

  • F.M.M.T. Marikar Department of Biochemistry, Faculty of Medicine and Allied Science, University of Rajarata, Saliyapura, Anuradhapura, Sri Lanka
  • M.M. Musthafa National Institute of Animal Science and Veterinary Medicine, China Agricultural University, 2 West Yuanmingyuan Road, Beijing 100193,China
Abstract:

The objective of this review is to explore the current developments on major genes working on prolific sheep breeds and the mechanism behind it, while identifying the future working points. Productivity is the ultimate goal of farm animal production and prolificacy is a key feature in determining productivity in farm animals. Ovulation rate in mammals is an intricate process involving genetics and endocrine pathways. Exceptional reproductive capabilities along with higher ovulation rates were observed in many breeds of sheep from different parts of the world since the discovery of Booroola Merino sheep. These naturally occurring mutations acting on prolificacy are found in chromosomes 5, 6, 11 and X but speculations are around about the presence of more mutations on these genes or different genes on multi ovulating sheep breeds. The exact control mechanism of multiple ovulations and multiple births in prolific sheep breeds is poorly understood. Over the years it has been repeatedly shown that gonadotropins and intra ovarian factors play vital and variety of roles. More specifically, follicular stimulating hormone regulation during folliculogenesis could be a promise for the future studies. Among those intra ovarian factors, bone morphogenic protein system is one of the indispensable components, which exerts enormous enthusiasm among the scientific community towards manipulating ovarian folliculogenesis. Rather surprisingly, biological and physiological roles of bone morphogenic protein subfamily are not thoroughly elucidated and contradictory findings among the mammals make further twists, which will be the gaps to be filled in the near future. Presence of a regulatory control loop between oocyte, granulosa and theca cells throughtransforming growth factor B(TGFB) superfamily is proposed here.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

an overview of major genes affecting prolificacy in sheep and related mechanisms

the objective of this review is to explore the current developments on major genes working on prolific sheep breeds and the mechanism behind it, while identifying the future working points. productivity is the ultimate goal of farm animal production and prolificacy is a key feature in determining productivity in farm animals. ovulation rate in mammals is an intricate process involving genetics ...

full text

Screening for Causative Mutations of Major Prolificacy Genes in Iranian Fat-Tailed Sheep

Objective The presence of different missense mutations in sheep breeds have shown that the bone morphogenetic protein receptor 1B (BMPR1B), bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) genes play a vital role in ovulation rate and prolificacy in ewes. Therefore, the present study investigates BMPR1B, BMP15 and GDF9 genes mutations in prolific ewes of Iranian ...

full text

An Overview of Calcium, Mechanisms and Necessities

Today, promoting quality of life and paying more attention to nutrition and health are among the major issues of international debate and governments' strategies to improve people's quality of life in different societies. There have also been extensive studies to improve nutrition and its relationship with health. The pattern of food consumption is different in most countries, different social ...

full text

Screening for Causative Mutations of Major Prolificacy Genes in Iranian Fat-Tailed Sheep

Background The presence of different missense mutations in sheep breeds have shown that the bone morphogenetic protein receptor 1B (BMPR1B), bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) genes play a vital role in ovulation rate and prolificacy in ewes. Therefore, the present study aims to investigate BMPR1B, BMP15 and GDF9 gene mutations in prolific ewes of I...

full text

faculty of psychology and social sciences group of anthropology master thesis in major of anthropology

چکیده پایان نامه (شامل خلاصه، اهداف، روش های اجرا و نتایج به دست آمده): کار جمع آوری گو یش های محلی در سال های اخیر شتاب امیدوار کننده ای به خود گرفته است. شاید از بارزترین اهداف جمع آوری گویش های مختلف، ثبت و ضبط آن، جلوگیری از نابودی و مهمتر از همه حل مشکلات دستوری زبان رسمی باشد. دقت در فرآیند های زبانی گویش های محلی نوع ارتباط مردم نواحی مختلف با پیرامون نشان را به ما نشان خواهد داد. از س...

Clinical Application and Functional Mechanisms of Intravenous Immunoglobulin: an Overview

Previous, Intravenous Immunoglobulin (IVIG) has been used for treatment of patients with immunodeficiency. However, recent studies have shown that IVIG is a suitable approach for treatment of inflammatory and autoimmune diseases. Although the exact mechanism of IVIG action is not well known, recent findings have demonstrated that IVIG impacts on expression and function of FC receptors of immuno...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 4  issue 2

pages  239- 246

publication date 2014-03-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023